The CRS systems utilises the phenomenon of autoflourescence in interstitial fluid, the ability of metabolic substances dissolved in the fluid between cells to fluoresce when stimulated with UV light. This is already widely used in dentistry, neurosurgery and many other areas of medicine.
The subject's hand is placed on the machine, a painless pulse of light is emitted and within seconds a comprehensive analysis is performed and fed back to a computer. The software then interprets the results of the test and displays an array of indicators, giving deep insight into the patient's metabolic state.
In addition, recommendations are made that can enhance the subjects condition - allowing use by both medical professionals and staff in fitness or wellness centres.
Non-Invasive and instant
The advantage of this newly developed method is not only the non invasive procedure but also the quick measurement and evaluation of data which for the first time enables the monitoring of the metabolic regulation without impairment of the patient, or the inconvenience of costly and lengthy laboratory tests.
Theorectical background
The benefits of metabolic analysis
Human metabolism is the sum of all life supporting biochemical and biophysical processes, differing from person to person, and altered during life periods. In addition to this, human metabolism varies due to many other factors such as physical or mental stress. Comprehensive insights into the current state of health of the human organism can be gained by metabolism analysis.
Currently, metabolism analysis uses the results of several single laboratory tests such as single organ function, immune and hormone system, lipid and mineral metabolism, etc.
For a comprehensive analysis of the actual health status other information is needed, e.g., about the status of regulation processes with respect to the immune and hormone system, the normal cell division and degradation system and the individual detoxication capacity against free radicals. This is of particular interest in the field of high performance sport, as an optimised training status is characterized by short recovery periods, e.g., an optimised regulation capacity.
Ideally, a comprehensive metabolism analysis should be able to detect individual deficiency of micronutrients, so that an individual mixture of micronutrients (in parallel with prescribed therapy) could be recommended for a directed regulation of any impaired metabolic process. Thereby the breakout of illness is reduced and convalescence supported. At the same time, an arbitrary combination or an over-dosage is avoided.
Disadvantages of blood samples
For a metabolism analysis and the determination of an individual need of micronutrients, an analysis of blood is required. The blood samples have to be sent to a specialized lab. The procedures are expensive and have several disadvantages. The results generally take several days to come back,. Because of transport, freezing, oxidation and duration until analysis, changes in the blood sample might occur which alter the measurement result. Besides this, taking a blood sample causes inconvenience and carries a slight risk (especially in tropical climates), at best, the patient suffers some distress. There may also be cultural or religious aversion to the taking of blood.
Non-invasive measurement of the actual metabolic situation - CRS system
To address these problems, Dr. Hermann Heinrich has developed a new method for non-invasive measurement of human metabolic status, which utilises the autofluorescence of metabolic substances excited by UV-light.
The advantage of this newly developed method is not only the non-invasive procedure but also the rapid measurement and interpretation, enabling the monitoring of metabolic regulation without impairment of the subject, and at a reasonable price.
Use of autofluorescence for medical diagnosis
The autofluorescence of cells, tissues and substances is based on the excitation of endogenous fluorophors (Definition: A fluorophor is a compound that emits light via fluorescence). Important endogenous fluorophors are for example tryptophan, coenzymes NADH and NADPH, and flavins.
Today, medical diagnosis uses this phenomenon successfully for early diagnosis of malignant tumors of the skin and mucous membrane of human cavities (endoscopic autofluorescence in the field of otolaryngology, surgery, internal medicine, gynecology, urology, dermatology and neurosurgery).
Laser-beam induced autofluorescence (quantitative light induced laser fluorescence: QLF) is routinely used in dentistry to diagnose tooth decay. In ophthalmology, autofluorescence is used for early diagnosis of macula degeneration, as this is the main cause of blindness of the elderly in the western world.
Measuring metabolic substances in interstitial fluid is meaningful as:
The intercellular capillary spaces (interstitial) are filled by a liquid which is in permanent contact with the lymph stream and blood circulation, as it mediates for example the transport of nutrients to, or metabolites from, and messenger substances between the cells. Changes of cellular metabolism or disordered cellular function vary the composition of the interstitial liquid in a specific manner, making the interstitial liquid ideally eligible for measuring both, temporary metabolic changes like physical of physiological stress, and metabolic disorders due to organ damage, or illness, as well as oxidative stress.
Development of the CRS system
The non-invasive CRS system is the further development of the so-called RSA - Redox-Serum-Analysis, which measures the redox potential in blood serum which has been incubated with certain metabolic substrates or stress factors respectively. Measured and computed redox potentials/values provide the basis for statements about the actual metabolic situation and its capacity against stress. In the meantime the RSA-data pool comprises about 1,2 million measurements which were approved by clinical diagnosis. Due to the invasive sample taking and the costly sample handling and measurement procedure the use of the RSA method is confined to a few specialized labs. Therefore, Dr. Heinrich developed since 1997 by comparative measurements the basis of the non-invasive CRS system.
How CRS gets results
The CRS system uses UV-light to excite the autofluorescence of metabolic substances like ATP, FAD, NADPH, etc. However, the autofluorescence of a single, or bundle of metabolic substances does not give any information about the actual health status of the volunteer. The combination of the single substances with each other in a specific manner enables the interpretation of any metabolic disorders or stress or regulatory disorders, respectively. Therefore, emitted fluorescence is analysed by the CRS system and well-ordered in specific terms, so that the pattern of distribution tells us about the state of health. The calculated parameters allow the following statements about the actual health status 'general performance capability':
- Metabolic regulation
- Protection from metabolic acidosis
- Immune resistance
- Connective tissue condition
- Regulation of inflammatory reactions
- Protection from oxidative stress
- Mental stress capacity
- Allergic activation
- Protection from infectious processes
- Cell regeneration processes
- Cell reduction processes
- General performance capability
- Micronutritional requirements
From these values, the CRS is able to detect gaps in the supply of micronutrients and provides information about individual supplemental needs.
Use of the CRS system in medicine
The CRS system provides through non-invasive analysis of metabolic regulation a unique health statement in a quickly and straight forward manner. Propositions about the generically metabolic activity, its regulation and the influence of inflammation, allergies, intoxications, viral or bacterial infections and so on are hereby possible. Consequently, a new application field of light induced autofluorescence is opened to the medicine.
The CRSmed is designed for GPs, Hospitals, and medically trained Practitioners to give a diagnosis using the Indicators contained in the analysis software. The ratio between different metabolic substances responsible for the chemical reaction in the cell metabolism allows diagnoses previously only available via a lengthy laboratory test. The Doctor can use the findings to establish, together with the history of the patient, in which area he has to investigate. The Doctor can also use these results to form the basis of advice about diet, lifestyle or nutritional changes.
CRS prevent for non-medicals
The CRSprevent is used in pharmacies, fitness or wellness centres. It gives a selection of those findings, which will enable you to give your client a statement about their general health status and, importantly, valuable advice about their personal nutritional needs and, when using CRSprevent for fitness/wellness, help to provide a personal training plan.
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